Gabapentin Teva

Gabapentin

Adjunctive therapy in the treatment of partial seizures w/ & w/o secondary generalization in adults & childn ≥6 yr. As monotherapy in the treatment of partial seizures w/ & w/o secondary generalization in adults & adolescents ≥12 yr. Treatment of peripheral neuropathic pain eg, painful diabetic neuropathy & post-herpetic neuralgia in adults.

Total daily dose should be divided in 3 single doses. Epilepsy Adult & adolescent Effective dose range: 900-3,600 mg daily. May be initiated by dose titration (day 1: 300 mg once daily; day 2: 300 mg bd; day 3: 300 mg tds), or 300 mg tds on day 1. Thereafter, can be increased in 300 mg daily increments every 2-3 days up to max 3,600 mg daily. Childn ≥6 yr Starting dose range: 10-15 mg/kg daily. Titrate over a period of approx 3 days to effective dose 25-35 mg/kg daily. Peripheral neuropathic pain Adult May be initiated by dose titration (day 1: 300 mg once daily; day 2: 300 mg bd; day 3: 300 mg tds), or 900 mg daily given as 3 equally divided doses. Thereafter, can be increased in 300 mg daily increments every 2-3 days up to max 3,600 mg daily. Patient w/ renal impairment: CrCl ≥80 mL/min Total daily dose: 900-3,600 mg daily, CrCl 50-79 mL/min Total daily dose: 600-1,800 mg daily, CrCl 30-49 mL/min Total daily dose: 300-900 mg daily, CrCl 15-29 mL/min Total daily dose: 150-600 mg daily, CrCl <15 mL/min Total daily dose: 150-300 mg daily. Patient undergoing haemodialysis 200-300 mg after every 4 hr of haemodialysis in addition to the maintenance dose of renally impaired patients. Loading dose in anuric patients who have never received gabapentin: 300-400 mg. Followed by 200-300 mg after every 4 hr of haemodialysis.

May be taken with or without food.

Hypersensitivity.

Risk of anaphylaxis or severe, systemic hypersensitivity reactions eg, DRESS; suicidal ideation & behaviour; occurrence of accidental injury (fall); severe resp depression. Monitor patients for signs of suicidal ideation & behaviours. Discontinue if patient develops acute pancreatitis during treatment. Abrupt w/drawal of anticonvulsants in epileptic patients may precipitate status epilepticus. Some patients may experience increase in seizure frequency or onset of new types of seizures w/ gabapentin. Not considered effective against primary generalized seizures eg, absences & may aggravate these seizures in some patients. Reports of cases of abuse & dependence. False +ve results in the semi-quantitative determination of total urine protein by dipstick tests. Patients w/ rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Concomitant use w/ opioids & other CNS depressants. Minor or moderate influence on the ability to drive & use machines. Should only be used during pregnancy & lactation if potential benefits outweigh risks. Childn & adolescents. Elderly >65 yr.

Viral infection; somnolence, dizziness, ataxia; fatigue, fever. Pneumonia, resp infection, UTI, infection, otitis media; leucopenia; anorexia, increased appetite; hostility, confusion & emotional lability, depression, anxiety, nervousness, thinking abnormal; convulsions, hyperkinesias, dysarthria, amnesia, tremor, insomnia, headache, sensations eg, paresthesia, hypaesthesia, coordination abnormal, nystagmus, increased/decreased/absent reflexes; visual disturbances eg, amblyopia, diplopia; vertigo; HTN, vasodilatation; dyspnoea, bronchitis, pharyngitis, cough, rhinitis; vomiting, nausea, dental abnormalities, gingivitis, diarrhoea, abdominal pain, dyspepsia, constipation, dry mouth or throat, flatulence; facial oedema, purpura, rash, pruritus, acne; arthralgia, myalgia, back pain, twitching; impotence; peripheral oedema, abnormal gait, asthenia, pain, malaise, flu syndrome; decreased WBC, wt gain; accidental injury, fracture, abrasion.

Reports of resp depression, sedation & death w/ CNS depressants including opioid. Reduced bioavailability w/ antacids containing Al & Mg.

Anticonvulsants / Drugs for Neuropathic Pain

N02BF01 - gabapentin ; Belongs to the class of gabapentinoids. Used to relieve pain and other conditions.

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